None listed
Conditions
Brief summary
Individuals with Chronic kidney disease (CKD) requiring dialysis treatment have a high risk of cardiovascular disease. It is thought that the process of dialysis may contribute to this risk by increasing oxidative stress and inflammation. In addition, individuals with non-diabetic CKD have are insulin resistant, similar to individuals with pre-diabetes. Insulin has been demonstrated to have anti-inflammatory properties. In very sick patients in Intensive Care, continuous insulin infusions have been associated with better outcomes. The impact of an insulin infusion during a haemodialysis session to reduce the inflammation generated by dialysis has not been studied. We propose a pilot study of an insulin infusion during dialysis to see if markers of inflammation measured in the blood are reduced. If there is evidence of improvement, we would then propose a longer time study to really see if there is benefit from insulin therapy.
Interventions
A randomised cross over study of a low dose insulin infusion (2 units/hr) during a standardised 4 hour haemodialysis session with a washout of 1 week between studies. The dialysis regime will remain unaltered between each session.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Stable non diabetic individuals on haemodialysis for at least 2 months. No clinical evidence of an acute illness or inflammation.
Exclusion criteria
Inability to give informed consent. Diabetic Smoker Intercurrent acute illness or inflammation. Established cardiovascular disease
Outcome results
None listed