None listed
Conditions
Brief summary
The primary purpose of the study is to determine whether measurement of total and free cortisol by mass spectrometry improves the diagnostic accuracy of synacthen tests to assess adrenal function in patients with pituitary disease.
Interventions
A 250 mcg synacthen test (250 mcg synacthen administered intramuscularly (IM) with cortisol measurements before and 30 and 60 minutes after synacthen) and a 1 mcg synacthen test (1 mcg synacthen administered intravenously (IV) with cortisol measurements before and 30 and 60 minutes after synacthen). These tests will be performed once each to each subject separated by approximately 7 days. The tests will be performed in healthy subjects (to define a normal reference range) and in subjects with pi
A 250 mcg synacthen test (250 mcg synacthen administered intramuscularly (IM) with cortisol measurements before and 30 and 60 minutes after synacthen) and a 1 mcg synacthen test (1 mcg synacthen administered intravenously (IV) with cortisol measurements before and 30 and 60 minutes after synacthen). These tests will be performed once each to each subject separated by approximately 7 days. The tests will be performed in healthy subjects (to define a normal reference range) and in subjects with pituitary disease previously defined as either adrenocorticotrophic hormone (ACTH) sufficient or deficient by current gold standard tests.
Sponsors
Department of Health, South Australia
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Pituitary patients: Clearly diagnosed with either ACTH sufficiency/deficiency Normal volunteers: Age 20-80 yrs
Exclusion criteria
Pregnancy, advanced malignancy, active infection, liver failure
Outcome results
None listed