None listed
Conditions
Brief summary
Week bones (osteoporosis) are an emerging problem in children and adults with cystic fibrosis (CF). When present, osteoporosis can cause bone pain, bone fragility, fracture and decrease quality of life. Bones develop during childhood and adolescence, however in CF the amount of bone that is made is reduced. Many factors work together to reduce the amount of bone made in children with CF. One major factor is that children with CF have less muscle than healthy children. The amount of muscle a child has affects the amount of bone that child can make. This is because the amount of bone made depends on the forces it is placed under and the greatest forces come from muscle pull on the bone during every day activity. One way to think of it is that the bigger the muscles the bigger and stronger the bones. As such, activity that increases the amount of muscle will increase the amount of bone. This may be because they do not participate in as much exercise as healthy children and cannot exercise as long as healthy children. Whole body vibration training (WBVT) using vibration plates can increase muscle with minimal effort required by the user. It may therefore be a very good way to increase the amount muscle and bone in children with CF, who often have difficulty exercising. WBVT has been shown to increase the amount of bone and muscle function in different groups of children and adults, including adults with CF. With this in mind, we plan to do a home base WBVT program in children and adolescents to see if WBVT increases the amount of bone and muscle they have. We will also look at muscle function and respiratory function.
Interventions
Whole body vibration training (WBVT) using a vibration platform.
WBVT using a vibration platform is a new, simple and safe training method that has been shown to improve muscle mass and bone density. WBVT has been used in a number of clinical settings including healthy athletes, untrained individuals, the elderly and in individuals with cystic fibrosis. It requires the participant to stand on a vibration plate that moves rapidly (10-20Hz) up and down over a small distance (10mm) generating a vi
Whole body vibration training (WBVT) using a vibration platform. WBVT using a vibration platform is a new, simple and safe training method that has been shown to improve muscle mass and bone density. WBVT has been used in a number of clinical settings including healthy athletes, untrained individuals, the elderly and in individuals with cystic fibrosis. It requires the participant to stand on a vibration plate that moves rapidly (10-20Hz) up and down over a small distance (10mm) generating a vibration stimulus. The vibration causes the muscles in the legs and body to contract resulting in increased muscle mass. WBVT is believed to stimulate bone formation due to the increased forces applied to the bone by the increased muscle mass seen after WBVT. The bone responds to these increased forces by altering its biomechanical properties (mineral content and geometry) to increase its density and strength. Participants will perform WBVT daily for six months on a vibration plate that will be placed in the participant’s home. Each daily session consists of four 3 minute WBVT sessions with short breaks in between each session. The total daily training time will take about 20 minutes.
Sponsors
The Children's Hospital at Westmead
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
Children and adolescents with cystic fibrosis aged between 6-18 years who can perform reproducible pulmonary function tests. Baseline forced expiratory volume in one second (FEV1) greater than 25% of predicted normal values.
Exclusion criteria
Long Bone or vertebral fracture within the preceding 6 months. Past or present history of arthritis. CF liver disease with portal hypertension. Inability to stand unaided for 30 minutes. Co-existent neuropathy or myopathy. Vitamin D deficiency (25-hydroxyvitamin D <39nmol/L) within last 3 months. Severe CF (FEV1 < 25% predicted). Use of medication known to interfere with bone metabolism. History of using any of the following medications, regardless of dose, for at least 1 month, within 3 months of enrolment: Anabolic agents, Oestrogen (except contraceptives), Progestogens (except contraceptives), Calcitriol, Calcitonin, Fluoride (except dental health products), Bisphosphonates, Growth hormone, Parathyroid hormone (PTH), Strontium.
Outcome results
None listed