None listed
Conditions
Brief summary
Dexamethasone is a drug commonly given to prevent postoperative nausea and vomiting. It also has properties that dampen the body's immune response to infection. In this study, we propose to examine female patients undergoing breast surgery. These patients are at high risk of nausea and vomiting and routinely receive drugs to prevent this. We will give patients one of two drugs, either dolasetron or dexamethasone when they are under anaesthetic. Blood samples will be taken before and after the drugs to determine the effect that they have on the immune system. We hope to determine whether dexathasone has an effect on the body's immune system.
Interventions
Granisetron 1mg, Dexamethasone 4mg or 8mg intravenously, single dose, after induction and immediately prior to surgery
Sponsors
Clinical A/Professor Tomas Corcoran
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Females undergoing breast surgery American Society of Anesthesiologists (ASA) Class I-III
Exclusion criteria
Current drug therapy with antiemetics, steroids or serotonergic antidepressants Active infection Known or suspected metastatic disease Previous chemotherapy treatment Patients receiving implants, such as mesh repairs Allergy/intolerance to any of the study drugs (including renal or hepatic impairment, active peptic ulcer disease, ischaemic heart disease, QT prolongation, major psychiatric illness) Diabetes mellitus or history of seizures Participation in any other research trial Pregnant or possibility of
Outcome results
None listed