Myocardial stress perfusion imaging with 320 slice multidetector computed tomography:- comparison with fractional flow reserve - pilot study

An evaluation of the accuracy of 320 slice multidetector computed tomography in detecting functionally significant coronary artery stenosis as compared against fractional flow reserve performed during coronary angiography.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12609000422224

Enrollment

Registered

2009-06-09

Start date

2009-07-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We aim to assss the accuracy of the 320 slice multidetector computed tomography in detecting stress myocardial ischemia against the known gold standard of fractional flow reserve, which is performed during invasive coronary angiography. We hypothesise that if found comparable, this may be important in evaluating the functional signficance of coronary artery disease in the general public.

Interventions

We are observing the relationship between the transmural perfusion ratio (TPR) obtained from 320 slice multidetector computed tomography, which is an measure of myocardial ischemia upon stress against the gold standard of fractional flow reserve during coronary angiography. The observations are performed within one month of each other.

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

Inclusion criteria: 1) Male greater than or equal to 40 years, Female greater than or equal to 50 years 2) Diagnosed coronary artery disease, with greater than or equal to 50% stenosis in one or more major epicardial vessels 3) Able to give informed consent

Exclusion criteria

Exclusion criteria: 1) History of anaphylaxis to iodinated contrast media 2) Recent myocardial infarction (last 7 days) where culprit vessel may require FFR assessment. 3) Prior Q wave-myocardial infarction in the vessel territory interrogated by FFR 4) Patient with history of coronary artery bypass grafting 5) Cardiogenic shock 6) Advanced atrioventricular (AV) block – including 2nd degree AV block with mobitz type II and 3rd degree AV block) 7) Chronic atrial fibrillation 8) New York Heart Association (NYHA) class 3-4 congestive cardiac failure 9) Left ventricular hypertrophy by electrocardiographic (ECG) critieria 10) Hypertrophic cardiomyopathy 11) Severe asthma (requiring long term oral steroid therapy) 12) Pregnancy or with child bearing potential 13) Severe renal insufficiency as obtained from estimated glomerular filtration rate (eGFR <60ml/min/1.73m2)

Outcome results