Improving pain relief following Total Knee Replacement

The effect of Continuous Femoral Nerve Infusion versus Conventional Analgesia on pain levels following Total Knee Arthroplasty: A prospective randomised, double blind, placebo controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000406202

Enrollment

100

Registered

2009-06-02

Start date

2009-05-27

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Studies have shown that femoral nerve infusions post total knee replacement may improve pain relief but a double blind, placebo controlled trial has not been conducted. Null hypothesis is that a continuous infusion of local anaesthetic for 48 hours post operation makes no difference to pain levels

Interventions

the treatment arm of the study will have a femoral nerve infusion of Bupivicaine 0.125% running at 10ml/hr for 48 hours after total knee replacement while the placebo will have saline running for 48 hours. all patients will have an intraoperative femoral nerve injection of 15ml Bupivicaine 0.25% along with subarachnoid blockade using 10-20mcg 0.5% bupivicaine + 3mcg/kg Morphine. Sedation using Midazolam/Propofol titrated to effect or General Anaesthetic (GA)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

18-85 years Body Mass Index (BMI) less than 40 undergoing primary total knee replacement ability to give informed consent

Exclusion criteria

BMI greater than 40 older than 85 contraindication to femoral nerve catheter major medical comorbidity

Outcome results