None listed
Conditions
Brief summary
Barrett’s oesophagus (BE) involves changes in the lining of the oesophagus and is a precursor for a type of oesophageal cancer. Obesity is a cause of BE and research suggests that certain hormones produced by fat tissue may be the mechanism through which obesity leads to cancer of the oesophagus. Exercise training may be an effective intervention in reducing oesophageal cancer risk given the strong links between BE, obesity and metabolic disturbances. There is some trial evidence that moderate-intensity exercise can improve obesity related hormone levels in overweight people without BE, but to date, no such evidence exists for patients with BE. By randomising patients with BE to either an exercise regimen or a stretching regimen, we aim to determine whether 24 weeks of moderate-intensity exercise will lead to changes in levels of certain hormones associated with oesophageal cancer development.
Interventions
Moderate-intensity exercise intervention consisting of: 30 min resistance training (2 sets of 8-12 repetitions, 8 exercises including bench press, leg press, seated row, assisted chin up, assisted tricep dip, shoulder press, lunges, core stability) and 30 min of cardiovascular training (60-70% maximum heart rate, including exercise bike, treadmill). 5 sessions per week for 24 weeks. One supervised session per week performed at a hospital. Four independent sessions performed at a local private gy
Moderate-intensity exercise intervention consisting of: 30 min resistance training (2 sets of 8-12 repetitions, 8 exercises including bench press, leg press, seated row, assisted chin up, assisted tricep dip, shoulder press, lunges, core stability) and 30 min of cardiovascular training (60-70% maximum heart rate, including exercise bike, treadmill). 5 sessions per week for 24 weeks. One supervised session per week performed at a hospital. Four independent sessions performed at a local private gymnasium.
Sponsors
Burns, Trauma and Critical Care Research Centre, School of Medicine, University of Queensland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Barrett's Oesophagus confirmed via the presence of intestinal metaplasia on biopsy and an abnormal appearance of the distal oesophagus via endoscopy. Overweight or obese (Body mass index 25-34.99kg/m2) Performing less than 60 min of moderate-intensity exercise per week for the previous 12 weeks. No loss or gain of >5kg of body weight during the previous 6 months.
Exclusion criteria
Serious medical impairments including: heart disease, lung disease, neurological disease, uncontrolled hypertension, diabetes, cancer, orthopaedic injuries.
Outcome results
None listed