A comparison of repetitive transcranial magnetic stimulation protocols in healthy volunteers for use in neurological disorders.

The effects of frequency and amplitude of low frequency repetitive transcranial magnetic stimulation of the motor cortex on motor evoked potentials, simple motor reaction times and strength in healthy human volunteers: a study to improve magnetic brain stimulation as a treatment for neurological disorders, especially stroke.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000393257

Enrollment

Registered

2009-06-01

Start date

2009-05-13

Completion date

2009-10-16

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Healthy volunteers will be treated with 10 minutes of repetitive transcranial magnetic stimulation of the motor cortex using 3 different (low) frequencies and 2 different amplitudes. Simple motor reaction times and motor evoked potentials will be studied immediately before and after, and after 30 minutes. The aim is to ascertain the optimal protocol for modifying the excitability of the motor cortex in neurological disorders.

Interventions

Repetitive transcranial magnetic stimulation (rTMS) will be performed with a Magstim Rapid2 stimulator using a 70 mm figure of 8 coil over the right motor cortex and will involve stimulation at frequencies of 1, 0.2 or 0.05 Hz and at amplitude of 80% or 110% of resting motor threshold (RMT) lasting 10 minutes.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy volunteers

Exclusion criteria

Neurological disease Epilepsy

Outcome results