None listed
Conditions
Brief summary
The prevalence of overweight and obese individuals has significantly increased in Australia over the past 20-30 years. Associated with high body mass is the increased the risks of type II diabetes, cardiovascular disease, high blood pressure, certain cancers, sleep apnoea, osteoarthritis, psychological disorders and social problems.Overall, the aim of this study is to examine the gene changes during weight loss and identify the potential gene targets of a high-protein diet that may be important for preservation of muscle mass. Different protein preparations could then be tested looking specifically at these gene changes. Those protein preparations identified as important for preservation of muscle mass will be reported as a beneficial inclusion in high-protein weight loss and may ‘aid’ in the maintenance of long-term weight reduction.
Interventions
Intervention of fortnightly consultation with a dietitian, providing meal plans and advice aiming for the consumption of 1500 calories (6000 kJ/day)of either a high-protein or a high-carbohydrate diet for 12 weeks.
Sponsors
CSIRO Human Nutrition
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Female, Aged between 40-60 years old, Body Mass Index (BMI) not greater than 40 or less than 27. Not currently participating in an exercise or weight loss program. Participants must understand the procedures involved and agree to participate in the study by giving full informed, written consent
Exclusion criteria
Previously diagnosed or currently taking hypoglycaemic medication for Type 1 or 2 diabetes, Fasting blood glucose of > 7.0 mmol/L, Known allergy to anesthetics, Any abnormality of clinical significance on medical history, Currently pregnant, planning pregnancy or breastfeeding, Currently participating in a physical activity program, Currently taking a caloric restricted diet, Taking antihypertensive or cholesterol-lowering medication e.g. Lipitor, Xenical, Zetia or Hyperium. Proteinuria, a malignancy, or a history of metabolic disease such as liver, kidney, cardiovascular, respiratory or gastrointestinal disease, Cardiac (heart) abnormalit(y)ies, Cigarette smoker within 6 months prior to study commencement, Regular heavy alcohol consumption (> 5 standard drinks/day).
Outcome results
None listed