Assessing in young Australian adults whether exposure to simulated solar ultraviolet radiation affects immune response to primary vaccination.

Assessing in healthy young Australian fair-skinned adults whether exposure to simulated solar ultraviolet radiation (UVR) affects immune response to primary vaccination.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000380291

Acronym

AusUVI

Enrollment

Registered

2009-05-28

Start date

2009-05-11

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to determine whether exposure to simulated solar ultraviolet radiation at levels relevant to normal daily activities can suppress the immune response to vaccination.

Interventions

The intervention group will receive 0.8 x minimal erythemal dose of simulated solar UVR daily for five days (via a calibrated UVR lamp) delivered to a 5x5cm area of skin over the lower thigh. On the day following the last dose of UVR, participants will be vaccinated with 125mcg of Keyhole Limpet Haemocyanin (KLH) with Montanide-ISA 51 adjuvant subcutaneously to the site of irradiation.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18 - 40 years * Fitzpatrick Type II-III skin (fair skin which sunburns without difficulty) * Willing and able to sign informed consent

Exclusion criteria

* Allergy to shellfish * Pregnancy or breastfeeding * Previous KLH vaccination * Immunosuppressive medications * Immunosuppressive medical condition * Recent infection (within 2 weeks of vaccination) * Recent immunisation with any other vaccine in past 4 weeks * Photosensitive skin or taking photosensitsing medication

Outcome results