None listed
Conditions
Brief summary
Dietary fibre and protein are thought to attenuate postprandial blood glucose levels. This study in 33 participants with type 2 diabetes, will compare glucose and insulin responses following consumption of drinks containing glucose with and without protein and fibre from two different sources: lupin and soy. It is proposed that: 1. Fibre and protein-enriched drinks (lupin and soy) will be associated with lower postprandial levels of glucose and insulin compared with the carbohydrate-matched control; and 2. The lupin-enriched drink will be associated with lower levels of glucose and insulin compared with the soy-enriched drink.
Interventions
A study of the acute effects of dietary fibre and protein from legumes (when added to drinks) on blood glucose and insulin levels will be assessed. Three treatments, administered in random order at least 1 week apart, will be compared – 1) lupin flour high in protein and fibre [50 g of flour containing 22 g protein and 12.5 g fibre], plus 50 g glucose; 2) Soy protein [22 g] and fibre [12.5 g] provided as a mixture of isolated soy protein and concentrated soy fibre, plus 50 g glucose; 3) 50 g gl
A study of the acute effects of dietary fibre and protein from legumes (when added to drinks) on blood glucose and insulin levels will be assessed. Three treatments, administered in random order at least 1 week apart, will be compared – 1) lupin flour high in protein and fibre [50 g of flour containing 22 g protein and 12.5 g fibre], plus 50 g glucose; 2) Soy protein [22 g] and fibre [12.5 g] provided as a mixture of isolated soy protein and concentrated soy fibre, plus 50 g glucose; 3) 50 g glucose (carbohydrate-matched control). Each treatment will be consumed as a 600 ml beverage, consumed over a 15 minute time period. Each treatment corresponds to a single clinic visit lasting 5 hours. Participants attend the clinic after a 12 hour overnight fast. A venous cannula will be inserted in the antecubital fossa vein and after a 15 minute rest baseline blood samples will be drawn. The treatment beverage is consumed, then blood samples are taken every 15 minutes for 1 hour, then every 30 minutes to 2 hours and then hourly to 4 hours.
Sponsors
University of Western Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Diagnosis of type 2 diabetes within the previous 10 years (confirmed by a general practitioner, or evident at screening with fasting glucose > 7 mmol/L); age 35-65 years; body mass index < 40kg/m2; glycated haemoglobin < 9%.
Exclusion criteria
Type 1 diabetes, insulin use, >10% change in body weight in previous 6 months, smoking currently or within the last 6 months, daily alcohol consumption >3 standard drinks for females and >4 standard drinks for males, known allergy to lupin/nuts/soy/dairy/wheat/ gluten, other major chronic illness, change in regular medications in previous 3 months.
Outcome results
None listed