None listed
Conditions
Brief summary
There is no good evidence to support any particular level of protein input in critical illness. Some studies have indicated a level above which there is no additional benefit to short-term indicators (such as nitrogen balance), but none of the studies have looked at the effects on concrete outcomes such as time in the intensive care unit, or functional measures after discharge. The aim of this study is to look at such concrete measures after administering two different levels of protein to patients who are fed intravenously. The hypothesis is that a higher level of protein will improve outcomes.
Interventions
Patients requiring intravenous (parenteral) nutrition in the intensive care unit will be randomised to receive one of two triple phase parenteral nutrition solutions for the duration of their need for parenteral nutrition while in the intensive care unit. The protein in the parenteral nutrition solution is in the form of a balanced set of amino acids. The higher-protein intervention solution has 53g of amino acids per 1000kcal.
Sponsors
Royal Prince Alfred Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
adult intensive care patients requiring parenteral nutrition - our intensive care unit is an adult unit by Department of Health criteria, that is it accepts patients from 16 years upwards and all patients in the unit will be eligible for the study.
Exclusion criteria
patients under 16 years of age
Outcome results
None listed