None listed
Conditions
Brief summary
The primary objective of this study is to investigate the acute effects of dietary flavonoids (quercetin) and nitrate on blood pressure, endothelial function and nitric oxide (NO) status in men and women.
Interventions
A randomised, controlled, cross-over (latin square) designed trial will be performed to investigate the acute effects of quercetin and nitrate on blood pressure, endothelial function and NO status. Each participant will complete 4 visits one week apart in random order. Prior to each visit participants will be asked to consume a standard low flavonoid, low nitrate meal for breakfast. For each visit participants will attend the School of Medicine and Pharmacology Research Unit at Royal Perth Hos
A randomised, controlled, cross-over (latin square) designed trial will be performed to investigate the acute effects of quercetin and nitrate on blood pressure, endothelial function and NO status. Each participant will complete 4 visits one week apart in random order. Prior to each visit participants will be asked to consume a standard low flavonoid, low nitrate meal for breakfast. For each visit participants will attend the School of Medicine and Pharmacology Research Unit at Royal Perth Hospital in the morning prior to lunch. The treatments will correspond to: 1. 200 mg quercetin + 200 mg nitrate as sodium nitrate (270 mg) 2. 200 mg quercetin + nitrate control (180 mg of sodium chloride) 3. quercetin control (no quercetin) + 200 mg nitrate as sodium nitrate (270 mg) 4. quercetin control (no quercetin) + nitrate control (180 mg of sodium chloride) Each of these treatments will be consumed dissolved in 200 ml of warm water and consumed over less than 1 min, immediately after a fixed energy lunch.
Sponsors
University of Western Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy non smoking men and women
Exclusion criteria
Exclusion criteria will include: 1. current or recent (<12 months) smoking 2. body mass index < 18 or > 35 kg/m2, 3. history of cardiovascular or peripheral vascular disease, 4. diagnosed diabetes, and non-diabetic individuals with fasting plasma glucose concentrations greater than or equal to 5.5 mmol/L, 5. a psychiatric illness, 6. other major illnesses such as cancer, 7. current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight), 8. reported lactating, pregnant or wishing to become pregnant during the study, 9. alcohol intake > 210 g per wk for women and > 280 g per wk for men, and 10. inability or unwillingness to consume foods/beverages provided.
Outcome results
None listed