The optimal volume of ropivacaine for pain relief after shoulder surgery

Optimising Analgesia after Shoulder Surgery: the optimum primary volume and dose of ropivacaine for continuous interscalene analgesia

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000347268

Enrollment

100

Registered

2009-05-25

Start date

2009-04-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

If the primary hypothesis is confirmed, this study will provide evidence supporting the use of a lower primary bolus dose via the interscalene catheter prior to shoulder surgery. Increased exposure of the techniques may promote their uptake in this setting.

Interventions

Up down staircase method (sequential allocation of dose depending on the response of the previous patient) for determination of ED50 of both ropivacaine volume and concentration (administered by perineural injection) starting at 30 mL and 0.5%. Once the ED95 for both the volume and concentration has been determined, this will be compared with ropivacaine 0.5% 30 mL. This is a one-off injection in each patient.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Patients requiring continuous interscalene analgesia for shoulder surgery under the care of the three investigators

Exclusion criteria

1. Patient refusal of block. 2. Known neuropathy involving the shoulder undergoing surgery. 3. Known allergy to amide local anaesthetic drugs.

Outcome results