The Effect Of Red Meat And Resistant Starch On Bowel Health

Dietary protein-induced Deoxyribonucleic acid (DNA) damage in the colon: the effect of a high red meat diet compared to a high red meat diet supplemented with Resistant Starch (RS) in healthy volunteers aged 50-75 years

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000306213

Enrollment

Registered

2009-05-19

Start date

2009-09-22

Completion date

2010-06-09

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to ascertain the effects on bowel health of resistant starch (StarPlus (trademark)) when given to participants who are ingesting a high red meat diet. Also to determine if the consumption of this high protein diet causes changes in certain markers for bowel cancer and if adding RS, ( StarPlus (trademark)) to the diet can improve these effects.

Interventions

Run in period (4 weeks consisting of normal diet with no added resistant starch) followed by 4 weeks of high red meat diet (300g per day) AND resistant starch 40g (20g twice a day, StarPlus (trademark) powder to be added to juice or custard), followed by a washout period (4 weeks consisting of normal diet) before moving onto 4 wks of a high red meat diet of 300g per day WITHOUT added Resistant starch.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Participants will be of an age 50-75 years. Healthy, with no active bowel disease.

Exclusion criteria

Evidence of any active mucosal bowel disease, eg colitis, or of malabsorption. Intolerance to high-fibre foods. Any perceived contraindication to consumption of the high protein diet. Previous bowel surgery (excluding polypectomy). Ingestion of regular laxatives or laxative derivatives (excluding regular fibre intake). Ingestion of regular probiotic complimentary medicines. Anitibiotic therapy in the previous four weeks.

Outcome results