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A Comparative study of airway pressures generated by non-invasive respiratory support used in cardiac surgical patients

A Comparative Study of airway pressures generated in cardiac surgical patients using nasal high flow and facemask continuous positive airway pressure (CPAP).

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12609000305224
Enrollment
15
Registered
2009-05-19
Start date
2009-05-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will compare the airway pressure generated in cardiac surgical patients receiving high flow humidified nasal oxygen therapy to that generated in the same patient when receiving non-invasive ventilation via a face mask.

Interventions

Patients undergoing cardiac surgery will be invited pre-operatively to participate in this study. Participants will have pressure measurements carried out with both Optiflow trademark and facemask non-invasive ventilation (NIV). Following surgery, whilst the participant is sedated and ventilated in the Intensive Care Unit, a 10F catheter will be inserted into the nasopharynx via the nose. Once the patient has been woken and extubated a baseline airway pressure measurement will be performed wh

Patients undergoing cardiac surgery will be invited pre-operatively to participate in this study. Participants will have pressure measurements carried out with both Optiflow trademark and facemask non-invasive ventilation (NIV). Following surgery, whilst the participant is sedated and ventilated in the Intensive Care Unit, a 10F catheter will be inserted into the nasopharynx via the nose. Once the patient has been woken and extubated a baseline airway pressure measurement will be performed while the patient breathes spontaneously on their routine oxygen therapy device e.g. standard nasal cannulae or facemask. Pressure measurements will be carried out following a random sequence for both the Optiflow trademark system and NIV delivered via a facemask. Participants will have 3 measurements performed on the Optiflow interface at 30, 40 and 50 litres per minute and 3 measurements performed on NIV at 4,6 and 8 cmH2O via a facemask. For each group, pressure measurement for each flow/pressure will be recorded over one minute of breathing using precision pressure transducer (PPT). This procedure is expected to take around 30 mins. The catheter will be removed at the end of this period.

Sponsors

Auckland City Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Consent has been obtained. Patient is over 18 years of age. Patient is to undergo cardiac surgery.

Exclusion criteria

The patient has significant nasal septum deviation. High flow nasal oxygen therapy is contraindicated. Non-invasive ventilation is contraindicated Following surgery the patient is unable to follow simple commands once awake and extubated.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 24, 2026