N-acetyl cysteine: could it be an effective adjuvant therapy in infertile women undergoing intra-cytoplasmic sperm injection (ICSI) in achieving more pregnancy?

In women undergoing intra-cytoplasmic sperm injection (ICSI) using gonadotropin releasing hormone agonist (GnRHa) long protocol, does addition of N-acetyl cysteine (NAC) in comparison to the standard protocol achieves more pregnancy?

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000274279

Enrollment

Registered

2009-05-15

Start date

2006-09-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The trial aims at testing the value of adding N-acetyl cysteine (as a powerful anti-oxidant) in achieving more pregnancies for infertile females undergoing intra-cytoplasmic sperm injection (ICSI) procedure using gonadotrophin releasing hormone agonist plus gonadotrophin ovarian stimulation.

Interventions

Triptorelin 0.1 mg subcutaneous injection daily from the midluteal phase of the pretreatment cycle followed directly by 1200 mg NAC orally daily in three divided doses (400mg each) starting from the first day of gonadotropin administration till the day of human chorionic gonadotrophin (hCG)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to 37 Years

Healthy volunteers

Inclusion criteria

Women undergoing ICSI cycles for male infertility

Exclusion criteria

Age > 37 years, body mass index < 18 or > 29 kg/m2, cycles < 24 days or > 35 days, single ovary, day 3 follicle stimulating hormone 9.5 milli international unit/ml or more, basal total antral follicle count 6 or less, cases refused to sign a consent

Outcome results