Effect of Vitamin D2 and Vitamin D3 on serum 25-hydroxyvitamin D and parathyroid concentrations in healthy adult participants

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Vitamin D is available in two forms, vitamin D2 and vitamin D3. Vitamin D3 is synthesized in the human body, whereas vitamin D2 is commonly used in supplements. It is not clear if the two forms have equivalent effects on serum 25-hydroxyvitamin D concentrations – the best measure of vitamin D status. To date, results of studies have yielded conflicting results because of problems with study design including small number of participants, short study duration and confounding effects of seasonal changes in serum 25-hydroxyvitamin D concentrations. We propose to evaluate the effects of daily doses of both vitamin D2 and vitamin D3 on serum changes in serum 25-hydroxyvitamin D and parathyroid concentrations over a sufficient period of time (4 mo). As most clinical and public health recommendations do not distinguish between vitamin D2 and D3, the results of this study will provide a definitive answer to whether these 2 distinct forms should be regarded as equivalent and interchangeable.

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