None listed
Conditions
Brief summary
The aims of the study are: 1. To examine if vitamin D deficiency is common problem in Aboriginal children in Western Australia (WA) 2. To determine if depot and daily vitamin D therapy have the same therapeutic outcomes. 3. To examine the relationship between vitamin D levels and childhood infections. 4. To determine the predictors of vitamin D deficiency in Aboriginal children We hyypothesize that: 1. Vitamin D deficiency is a common problem in Aboriginal children in WA 2. Depot vitamin D therapy results in better therapeutic outcomes than traditional daily vitamin D therapy. 2. Children with lower vitamin D levels have a higher burden of childhood infections. 3. Age, sun exposure, skin pigmentation and nutrition will influence vitamin D levels in children
Interventions
Depot vitamin D3 supplementation (200,000IU, oral route, once every 6 weeks with 6 weekly maintenance of 35,000IU continued for a duration of 6 months)
Sponsors
Jason K Tan
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to 16 Years
Healthy volunteers
No
Inclusion criteria
1. Aboriginal children aged 0-16 years old 2. Attending hospital or attending outpatient clinics 3. Require a blood test as part of their clinical management 4. Have a low vitamin D level (<78nmol/L)
Exclusion criteria
1. Children already diagnosed with low vitamin D levels and are receiving vitamin D supplementation 2. Children with immune deficiency 3. Children with chronic liver disease 4. Children with chronic renal disease 5. Children with cardiac disease 7. Children taking anticonvulsant medication
Outcome results
None listed