The influence of differing inspired oxygen concentrations on platelet function in a model of ischaemic reperfusion injury

A trial of patients with an upper limb arterial tournique and whether an increase in inspired oxygen concentration at the time of reperfusion has any effect on platelet activation, as assessed by flow cytometry and thromboelastography

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000183280

Enrollment

Registered

2009-04-17

Start date

2009-03-23

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Increasing the fractional inspired oxygen concentration to 0.5 and 0.8 from 0.3 at the time of reperfusion. This is achieved by altering oxygen concentration on the ventilator. This is a one off treatment started 10 minutes before tourniquet release and continued until 30 minutes after tourniquet release.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Adult patients undergoing upper limb surgery that requires the use of a tourniquet for more than 45 minutes 2. American Society of Anaesthesiology (ASA) grade 1 or 2

Exclusion criteria

1. Patients taking any antiplatelet medication 2. Confirmed coagulation disorder (pathological or drug induced) 3. Platelet count less then 80 x 109/l 4. Blood urea greater than 8.0 mmol/L 5. Systemic infection 6. Confirmed systemic Inflammatory diseases 7. Documented pregnancy 8. Documented malignancy 9. Trauma other than the ipsilateral upper limb 10. Multiple tourniquet episodes 11. Likely intraoperative O2 requirement > 30%

Outcome results