The acute effects of whey protein isolate on metabolic syndrome risk factors in overweight and obese individuals

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000178246

Enrollment

Registered

2009-04-17

Start date

2009-03-05

Completion date

2009-07-07

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The prevalence of overweight/obesity is currently exploding with over 60% of Australian adults in this category, leading to a rapid increase in diabetes, hypertension, and cardiovascular disease (CVD). Increased dairy consumption has been demonstrated to significantly benefit weight loss. Initially, it was thought that diary calcium was the reason for these health benefits, but recent studies have shown that this is not the case. Attention is now focused to other dairy components, such as dairy proteins. Although there is no clinical evidence in humans to support this, exciting new research from animal studies have shown that dairy whey-protein isolate (WPI) can reduce body weight, lower plasma lipids, improve, blood pressure and insulin action. There is an urgent need to provide the scientific evidence to clarify whether the protein component is responsible for the observed association between dairy consumption and body weight. Therefore the aim of this study was to investigate whether acute ingestion of WPI affects postprandial lipemia, insulin sensitivity and endothelial function in overweight/obese adults.

Interventions

Randomised, single-blind, cross-over design study which invesigates the postprandial response to the acute ingestion of either a liquid preload of 50g of whey protein isolate, casein protein or glucose (control) mixed in 400 mls of water, over 3 visits, one day a week for 3 consecutive weeks.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

45 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

Post-menopausal Non-smoker Body mass Index (BMI) between 25-35 kg/m2 Not taking regular medication Not taking supplements, vitamins or herbal remedies Weight stable Less than 1-2 serves dairy per day No major diseases/illness

Exclusion criteria

Smokers Regular medications, especially those affecting blood lipids, blood pressure or thyroid Premenopausal or perimenopausal On a weight loss regime

Outcome results