None listed
Conditions
Brief summary
The prevalence of overweight/obesity is currently exploding with over 60% of Australian adults in this category, leading to a rapid increase in diabetes, hypertension, and cardiovascular disease (CVD). Increased dairy consumption has been demonstrated to significantly benefit weight loss. Initially, it was thought that diary calcium was the reason for these health benefits, but recent studies have shown that this is not the case. Attention is now focused to other dairy components, such as dairy proteins. Although there is no clinical evidence in humans to support this, exciting new research from animal studies have shown that dairy whey-protein isolate (WPI) can reduce body weight, lower plasma lipids, improve, blood pressure and insulin action. There is an urgent need to provide the scientific evidence to clarify whether the protein component is responsible for the observed association between dairy consumption and body weight. Therefore the aim of this study was to investigate whether prolonged, chronic consumption of WPI will promote weight loss and improve CVD risk factors in the overweight/obese. The hypothesis for this study was that consumption of dairy whey-protein isolate will improve cardiovascular health/metabolic syndrome by reducing plasma lipids, blood pressure, arterial stiffness, inflammatory markers, enhanced glucose tolerance, endothelial function and insulin action.
Interventions
Chronic, randomized, parallel design study with 3 intervention groups where subjects consume 30g of either whey protein isolate, casein protein or glucose (control) in powder form mixed with 250ml water twice a day over a 12 week period while maintaining their usual diet and exercise regime
Sponsors
Dairy Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Body Mass Index (BMI) between 25-35kg/m2 Not on regular medications Non-smoker Have low dairy intake (<1-2 serves/day) Less than 1 alcoholic drink/day for women, 2 for men Weight stable No major diseases or disorders
Exclusion criteria
Smokers On regular medications, especially those affecting blood pressure, thryoid, blood lipids High consumption of dairy or alcohol Taking regular supplements, vitamins, herbal remedies On a weight loss regime
Outcome results
None listed