None listed
Conditions
Brief summary
We aim to examine the effect of exercise, compared to chest physiotherapy and control, on mechanisms of airway clearance in cystic fibrosis. We hypothesise that exercise and chest physiotherapy will improve respiratory flow rates and properties of mucus.
Interventions
Group 1: Treadmill exercise, speed and incline set to achieve an exercise intensity of 60% of each subject's peak oxygen uptake (VO2) for 20 minutes on one occasion. Peak VO2 measured on the day prior to randomisation.
Group 2: Chest physiotherapy. Subjects breath out through a Flutter device which provides an oscillating expiratory pressure at the mouth of 10-20cmH2O. Subjects breath out through this device for two minutes, followed by the Forced Expiratory Techinique. This cycle is repeated si
Group 1: Treadmill exercise, speed and incline set to achieve an exercise intensity of 60% of each subject's peak oxygen uptake (VO2) for 20 minutes on one occasion. Peak VO2 measured on the day prior to randomisation. Group 2: Chest physiotherapy. Subjects breath out through a Flutter device which provides an oscillating expiratory pressure at the mouth of 10-20cmH2O. Subjects breath out through this device for two minutes, followed by the Forced Expiratory Techinique. This cycle is repeated six times in a 20 minute period on one occasion. Group 3: Control (resting breathing). Sitting quietly, relaxed breathing for 20 minutes on one occasion. There is a minimum of 24 hours "wash out" between interventions. All three interventions to be completed within two weeks
Sponsors
Royal Prince Alfred Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
diagnosed with cystic fibrosis, stable clinical condition
Exclusion criteria
previous lung transplant, pregnant
Outcome results
None listed