The effects of memantine versus placebo on visual functions after scleral buckling for regmatogenous retinal detachment (RRD)

The effects of memantine versus placebo on visual acuity , optical coherence tomogapy (OCT) , contrast sensitivity , multifocal electroretinography (mERG) after scleral buckling for regmatogenous retinal detachment (RRD)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000111279

Enrollment

Registered

2009-02-18

Start date

2008-02-20

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Evaluation of the neuroprotective effect of Memantine in visual function of patients with macula off RRD of less than 1 months duration. Our hypothesis was that Memantine helps for better improvement of visual function in these patientsafter successful scleral buckling.

Interventions

intervention: Memantine tablets for treatment group for 3 weeks orally(5mg/day for the first week and 10 mg/ day for the next two weeks)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

Macula off rhegmatogenus retinal detachment (RRD) Duration<4 weeks Proliferative vitreoretinopathy (PVR) A ;B Visual acuity (V/A) < 20/200

Exclusion criteria

Usage of digoxin and dextrometorphan (interacting with memantine) Pregnancy an nursing Renal disease Failure of surgery Longstanding retinal detachment (RD) Other macular pathology

Outcome results