None listed
Conditions
Brief summary
Obstructive sleep apnoea is a common and treatable condition characterised by upper airway (throat) collapse which results in the repeated cessation of breathing during sleep. It is associated with disrupted sleep and excessive daytime tiredness and lethargy, which have major consequences for social well-being and productivity in our community. It is association with hypertension and is an independent risk factor for cardiovascular disease. Upper airway muscle activity is important in the pathogenesis of obstructive sleep apnoea, both in the development of upper airway collapse and in the restoration of an open airway. The gold standard method of measuring muscle activity by the use of intramuscular electrodes. This technique while relatively painless is invasive as the skin must be punctured. A catheter based technique may allow non-invasive measurement of muscle activity without puncturing the skin. The purpose of this study is to (i) compare the effectiveness of intramuscular recordings of muscle activity with catheter-based recordings of muscle activity and (ii)to determine the role of the upper airway muscles (specifically the genioglossus, geniohyoid, tensor palatini and levator palatini) in maintaining an open airway with inspiratory loading (i.e. increased effort to breathe) during wakefulness and sleep in normal, healthy individuals and individuals with sleep apnoea.
Interventions
Each participant will have two small catheters inserted into the upper airway (throat) and oesophagus via the nose. Fine wire electrodes will be inserted into the genioglossus, geniohyoid, tensor palatini and levator palatini muscles. The catheters and wires will be inserted in the late afternoon and remain in place until the following morning (approximately 15 hours total). These wires and catheters will allow measurement of the activity of the upper airway muscles during wakefulness and sle
Each participant will have two small catheters inserted into the upper airway (throat) and oesophagus via the nose. Fine wire electrodes will be inserted into the genioglossus, geniohyoid, tensor palatini and levator palatini muscles. The catheters and wires will be inserted in the late afternoon and remain in place until the following morning (approximately 15 hours total). These wires and catheters will allow measurement of the activity of the upper airway muscles during wakefulness and sleep to determine which muscles are important in maintaining an open airway and how they may be failing to allow upper airway collapse in patients with sleep apnoea.
Sponsors
Sir Charles Gairdner Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Age >18yrs Without uncontrolled hypertension, without type 1 diabetes or uncontrolled type II diabetes, without cardiovascular disease. Healthy individual or diagnosis of obstructive sleep apnoea
Exclusion criteria
Age <18 years Uncontrolled hypertension type 1 diabetes uncontrolled type II diabetes cardiovascular disease
Outcome results
None listed