Investigation of Caspofungin Eye Drops for the Treatment of Fungal Eye Infections

Ocular Penetration of Caspofungin Eye Drops in the Treatment of Fungal Keratitis

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000066280

Enrollment

Registered

2009-01-27

Start date

2009-04-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This proposed study is intended to investigate if the antifungal drug, caspofungin, when applied as an eye drop is able to penetrate into the human eyes. The use of caspofungin as an eye drops in human has never been reported. Caspofungin eye drops are anticipated to safely penetrate into the human eyes when applied as eye drops and to achieve adequate concentrations to treat fungal eye infections.

Interventions

One drop of 0.5% Caspofungin eye drops will be administered hourly into the eye that will be operated on (commencing 4 hours before participant's elective surgery).

Study design

Allocation

Non-randomised trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Patients attending for elective eye surgery (eg. cataract surgery)

Exclusion criteria

Participants in whom the use of caspofungin is contraindicated (eg. pregnancy, hypersensitivity to caspofungin or its formulation, risk of clinically significant drug interactions or as per caspofungin's product information guide)

Outcome results