Skip to content

Evaluation of the efficacy of different strategies to treat anemia in Mexican children

Evaluation of the efficacy of different strategies to treat anemia in Mexican children: A randomized clinical trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12609000061235
Enrollment
266
Registered
2009-01-23
Start date
2003-03-10
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Anemia continues to be a major public health problem in many regions of the world and it is still not clear which strategy is more effective in children population in terms of adherence and efficacy. This study aimed to evaluate the efficacy and acceptance of several strategies that have been recently recommended to treat anemia.

Interventions

Children consumed on a daily basis during 4 months one of the following treatments: 1.- A standard ferrous sulfate supplement made in liquid solution. The daily dosage was 1mL containing ferrous sulfate (20mg). 2.- A daily iron and folic acid recommendation of UNICEF to treat anemia in a liquid solution. The daily dosage was 1mL containing iron (12.5mg) and folic acid (50ug). 3.- A multiple micronutrients supplement following a formula designed to treat anemia in indigenous population in Mexico

Children consumed on a daily basis during 4 months one of the following treatments: 1.- A standard ferrous sulfate supplement made in liquid solution. The daily dosage was 1mL containing ferrous sulfate (20mg). 2.- A daily iron and folic acid recommendation of UNICEF to treat anemia in a liquid solution. The daily dosage was 1mL containing iron (12.5mg) and folic acid (50ug). 3.- A multiple micronutrients supplement following a formula designed to treat anemia in indigenous population in Mexico. The daily dosage was 1mL containing iron (10mg), zinc (10mg), thiamine (0.6mg), Riboflavin (0.55mg), pyridoxin (0.75mg), vitamin B12 (0.55 ug), folic acid (37.5ug) and vitamin C (30mg). 4.- A powdered complementary food designed for a national program in Mexico (Oportunidades program formerly called Progresa program). The powder was prepared with a small amount of water to form a porridge which was eaten with the help of a spoon. The daily dosage was 44g containing iron (2.5mg), zinc (2mg), thiamine (0.18mg), riboflavin (0.32mg), vitamin B12 (0.42ug), folic Acid (10.1ug), vitamin C (2.4mg), vitamin A (330UI), vitamin E (2.5mg), vitamin D (100UI), vitamin B6 (0.2mg), vitamin K (6ug), niacin (2.3mg), pantothenic acid (0.6mg), biotin (4ug), calcium (200mg), phosphorus (160mg), magnesium (20mg), iodine (38ug), manganese (0.26mg), cupper (0.18mg), potassium (300mg) ahd chloride (220mg). 5.- A drink water product fortified with iron, zinc and ascorbic acid developed by Procter and Gamble (Cincinnati, OH). Water should be consumed when giving drinking water and when cooking for the child, there was no specified dose. 1L of watter contained iron (7.5mg), zinc (6.25mg) and vitamin C (50mg).

Sponsors

Universidad Autonoma de Queretaro
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
6 Months to 42 Months
Healthy volunteers
No

Inclusion criteria

Hemoglobin concentration <11.7g/dL

Exclusion criteria

Breastfeeding Chronic gastroenteritis or any other severe illness.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026