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Assessment of the generation of respiratory pressure by high flow nasal prongs using pressure measuring and lung imaging techniques

An investigation of cardiac surgical patients receiving nasal high flow therapy using a pressure measuring transducer and electrical impedence tomography to assess nasopharyngeal pressure and functional residual capacity

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12609000037202
Enrollment
20
Registered
2009-01-19
Start date
2008-12-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

After cardiac surgery the lungs may suffer from a small amount of collapse and may require extra assistance to re-expand. If this occurs nasal high flow therapy may be applied (delivery of warmed and humidified medical gas via the nose at flow rates up to 50 L/min). It is believed that this flow generates a degree of positive pressure in the lungs which is beneficial to patients with some degree of lung collapse. Assessment of the physiological effect by two different methods (pressure measurement in the upper airway and by a lung imaging technique called electrical impedence tomography) will help doctors understand the effects of this therapy better and will form the basis for future research in this area.

Interventions

Following cardiac surgery, patients who are already receiving Nasal High Flow (NHF) as part of their usual care will be approached to participate in this study (NHF = blended air and oxygen which has been warmed and humidified and delivered via nasal cannula at flows of up to 50L/min. Patients may receive this therapy for a few hours or a few days depending on their clinical condition). The research procedure is as follows: 1 Informed consent 2 Insert pressure measuring catheter into the patien

Following cardiac surgery, patients who are already receiving Nasal High Flow (NHF) as part of their usual care will be approached to participate in this study (NHF = blended air and oxygen which has been warmed and humidified and delivered via nasal cannula at flows of up to 50L/min. Patients may receive this therapy for a few hours or a few days depending on their clinical condition). The research procedure is as follows: 1 Informed consent 2 Insert pressure measuring catheter into the patient’s nasopharynx. 3 Attach belt of electrodes around patient’s chest. 4 Change from NHF to face mask oxygen therapy 5 10 -15 min wash out period 6 Arterial blood gas taken if Arterial line is in situ 7 Simultaneous pressure measurements and electrical readings recorded for a 2 min period. 8 Change from face mask oxygen therapy to NHF 9 10 - 15 min wash out period 10 Arterial blood gas taken if arterial line is in situ 11 Simultaneous pressure measurements and electrical readings recorded for a 2 min period 12 Remove pressure measuring catheter 13 Remove belt of electrodes 14 Continue with usual care Patients will receive the same concentration of oxygen with either therapy and this will be dictated by the patient’s clinical requirements. Physiological and demographic data from the patient’s medical chart will also be recorded.

Sponsors

Fisher and Paykel Healthcare
Lead SponsorCommercial sector/Industry

Study design

Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 95 Years
Healthy volunteers
No

Inclusion criteria

Patients following cardiac surgery requiring treatment with nasal high flow therapy

Exclusion criteria

Air leak syndrome Patient requiring electrical pacing via temporary pacing wires Patient with an open sternum Patient requiring noninvasive ventilation who cannot tolerate being off this for 15 minutes or greater

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026