None listed
Conditions
Brief summary
Wound infection following general surgical operations is a serious problem. As the number of the surgical procedures performed is large, any intervention having the potential to decrease this morbidity even by a small fraction will be beneficial. The most important barrier to infection is a healthy, well vascularized wound. A cream containing benzyl-nicotinate dilates the capillaries and small vessels and increases the blood flow in the skin and subcutaneous tissues when applied to the skin. In this study, the effect of this vessel dilating cream will be assessed on wound infection in patients undergoing general surgical operations.
Interventions
A topical cream containing benzyl nicotinate will be applied on the site of planned surgical incision. This molecule has a distinct vasodilative effect peaking at the 10th minute of application which lasts about 45 minutes. The cream which contains benzyl nicotinate also contains etofenamate; an antiinflammatory agent. The cream is placed in a syringe with the needle removed. The cream is applied to the incision with a dose of 1 mg benzyl nicotinate applied to each cm of the wound (1 ml cream/10
A topical cream containing benzyl nicotinate will be applied on the site of planned surgical incision. This molecule has a distinct vasodilative effect peaking at the 10th minute of application which lasts about 45 minutes. The cream which contains benzyl nicotinate also contains etofenamate; an antiinflammatory agent. The cream is placed in a syringe with the needle removed. The cream is applied to the incision with a dose of 1 mg benzyl nicotinate applied to each cm of the wound (1 ml cream/10 cm). The cream is applied on the operating table on the planned incision. The necessary amount will be distibuted homogenously on the planned incision with a width of 1 cm. Then the skin is prepared and draped. The surgery goes on as usual. The observation period is 30 postoperative days.
Sponsors
Baskent University
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All general surgical patients needing a skin incision.
Exclusion criteria
The patients who refuse to participate, operations involving perianal region, burn patients, patients undergoing a secondary operation within 30 days unless the reason is the surgical site infection.
Outcome results
None listed