Tyrosine Randomised Controlled Trial in Anorexia Nervosa

In female adolescents with anorexia nervosa, does supplementation with L-tyrosine, when compared with usual treatment alone, lead to improvements in eating disorders psychopathology?

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000007235

Enrollment

Registered

2009-01-07

Start date

2009-05-01

Completion date

2011-07-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The current study aims to investigate the effectiveness of tyrosine (an amino acid found naturally in protein foods) in the treatment of adolescent females with anorexia nervosa. The design of the study is a double-blind randomized control trial (RCT). The design will allow for the investigation of the effects of tyrosine in the study population, the testing of process measures, and exploration of recruitment and loss to follow up in clinical trials in people with anorexia nervosa.

Interventions

L-tyrosine approximately 100mg/kg/day administered orally in capsule form for twelve weeks

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

12 Years to 18 Years

Healthy volunteers

Inclusion criteria

Female adolescents with anorexia nervosa

Exclusion criteria

males, children (< 12 years) and adults (18 years and over), those with current (or within 6 months) drug or alcohol abuse, use of dietary tyrosine (or other amino acid) supplements within the previous 12 weeks, medically unstable patients, those with concurrent severe medical or neurological illness and participants with Phenylketonuria (inability to convert phenylalanine to tyrosine) and participants requiring noradrenergic or combined noradrenergic medications

Outcome results