None listed
Conditions
Brief summary
The primary purpose of the study is to determine whether or not acute administration of amphetamine produces schizophrenic-like brain function and cognitive effects.
Interventions
0.45 mg/kg (oral) dose of dexamphetamine administered once
Sponsors
Mathew Martin-Iverson
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
healthy
Exclusion criteria
1. Pregnancy or currently breastfeeding 2. hearing disorders 3. neurological disorders or known seizure risk 4. history of loss of consciousness for over 15 min 5. current diagnosis or treatment for a mental illness 6. past or current treatment for substance use disorder 7. significant risk of psychosis 8. presence or history of a kinetic disorder 9. presence or history of hypertension 10. presence or history of hepatic insufficiency 11. presence renal insufficiency 12. presence or history of cardiovascular disorder 13. significant risk of suicide 14. known hypersensitivity to amphetamines 15. receiving any systemic prescription medication (excluding contraceptives)
Outcome results
None listed