A randomised controlled blinded trial to investigate the effect of hyoscine butylbromide during colonoscopy on rates of polyp detection.

In patients undergoing standard fibreoptic colonoscopy at a single centre, randomly allocated to receive hyoscine butylbromide or saline; a comparison of polyp detection rates between the two groups is to be undertaken to improve detection of colonic polyps.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000600347

Enrollment

300

Registered

2008-12-01

Start date

2008-12-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Some colonic polyps are not seen during colonoscopy, and new therapies are frequently tested to decrease the 'miss-rate' of around 15-20 %. The aim of this study is to test the hypothesis that using an antispasmodic drug (hyoscine butylbromide - also known as buscopan), given as a single intravenous dose during colonoscopy, that polyp detection rates may be improved. The study population will be all patients (who agree to participate)booked in for routine colonoscopy for any indication at a university hospital centre.

Interventions

During the isolated procedure of a single colonoscopy using the standard equipment, monitoring and sedation; the intervention (a single dose of hyoscine butylbromide 20 mg intravenously over approximately 10 seconds, also commercially known as buscopan) will be administered upon intubation of the caecum.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

16 Years to 100 Years

Healthy volunteers

Inclusion criteria

Booking for colonoscopy. Intact colon (no previous colonic resection).

Exclusion criteria

Emergency colonoscopic procedure Previous colon resection Already included in this study Glaucoma Achalasia Previous urinary retention Known bowel obstructions Myasthenia gravis Porphyria Fructose intolerance Megacolon

Outcome results