Management of subclinical Cushing's syndrome in adrenal incidentalomas

Surgical versus conservative management for subclinical Cushing's syndrome in adrenal incidentalomas.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000567325

Acronym

No acronym

Enrollment

Registered

2008-11-12

Start date

1991-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We compared the clinical outcome of patients with subclinical Cushing’s syndrome due to an adrenal incidentaloma randomly assigned to undergo surgery (n = 23) or close follow-up (n = 22). Laparoscopic adrenalectomy was more beneficial than conservative management for subclinical Cushing’s syndrome patients complying with our selection criteria.

Interventions

Laparoscopic adrenal surgery. This involves the removal of the adrenal gland by laparoscopic instruments via a transperitoneal lateral approach. This is the only surgical procedure we perform in this trial

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

No clinical signs of cortisol excess and failure to suppress serum cortisol using the dexamathasone test

Exclusion criteria

Adrenal mass > 3.5 cm in diameter

Outcome results