None listed
Conditions
Brief summary
To identify the proteins and lipids that deposit on a lens surface and to determine which proteins and lipids mediate bacterial adhesion to the lens surface.
Interventions
Lens care solution crossover during 2 months daily wear (i.e. wear lenses during the day and remove lenses prior to sleep) of silicone hydrogel lenses. 1 month extended wear (continuous wear during the day and night) of silicone hydrogel lenses. There is a 1 calender day washout between treatments. At start of daily wear, each group will be randomly assigned to use either Optifree-Replenish (Alcon, USA) or Menicare Soft (Menicon, Japan) lens care solution. After one month daily wear, subjects wi
Lens care solution crossover during 2 months daily wear (i.e. wear lenses during the day and remove lenses prior to sleep) of silicone hydrogel lenses. 1 month extended wear (continuous wear during the day and night) of silicone hydrogel lenses. There is a 1 calender day washout between treatments. At start of daily wear, each group will be randomly assigned to use either Optifree-Replenish (Alcon, USA) or Menicare Soft (Menicon, Japan) lens care solution. After one month daily wear, subjects will be dispensed with the alternate lens care solution. Subjects will continue with this solution for the duration of the trial (i.e. one further month of daily lens wear and 1 month of extended lens wear).
Sponsors
Institute for Eye Research
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Be able to read and comprehend English and give informed consent as demonstrated by signing a record of informed consent; Be at least 18 years old; Be willing to comply with the wearing and clinical trial visit schedule as directed by the Investigator; Have ocular health findings considered to be 'normal' and which would not prevent the participant from safely wearing contact lenses; Have experienced an ocular adverse event that is not considered to be severe by the Investigator (Investigator discretion) or that is temporary in nature; Is correctable to at least 6/12 (20/40) or better in each eye with contact lenses; Be experienced or may be inexperienced at wearing contact lenses
Exclusion criteria
Pre-existing ocular irritation, injury or condition that would preclude contact lens fitting and safe wearing of contact lenses; any systemic disease that adversely affects ocular health; active corneal infection or any active ocular disease that would affect wearing of contact lenses; previously experienced a severe contact lens related adverse event (Investigator discretion), that is likely to affect their contact lens wear experience or present a significant safety risk during the trial; any prescribed systemic medication or topical medications which may alter normal ocular findings/are known to affect a participant’s ocular health/physiology or contact lens performance either in an adverse or beneficial manner; previous corneal refractive surgery; contraindications to contact lens wear; currently enrolled in another clinical trial; participation in a clinical trial within the previous 2 weeks;pregnant or lactating women who are not able to complete the study (Investigator discretion).
Outcome results
None listed