None listed
Conditions
Brief summary
It is well known that high amounts of oxygen can be harmful to patients with emphysema when they come to the emergency department. There is also a small amount of research to suggest that it could be harmful to patients with severe asthma as well, although they are routinely given high flow oxygen. The main purpose of this study is to see if giving 100% oxygen to asthmatics causes a rise in harmful carbon dioxide, and if so, what is the mechanism?
Interventions
100% oxygen inhaled for 20 minutes through a CPAP mask and tubing. Intervention will be administered to 3 groups of subjects: 1. 18 subjects with Asthma 2. 18 subjects with Chronic Obstructive Pulmonary Disease 3. 18 normal subjects (no respiratory disease)
Sponsors
Kyle Perrin
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Diagnosis of asthma 2. Forced Expiratory Volume in one second (FEV1) < or = 60% predicted
Exclusion criteria
1. Diagnosis of COPD 2. Current or ex cigarette smoking of > 10 pack years 3. Risk factors for hypercapnic respiratory failure (Body Mass Index > 40, severe musculoskeletal weakness, chest wall restriction).
Outcome results
None listed