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Ultrasound guided transversus abdominis plane (TAP) block for analgesia after caesarean surgery.

In women having caesarean sections, do transversus abdominis plane blocks, when compared to placebo, reduce morphine requirements?

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12608000540314
Enrollment
50
Registered
2008-10-27
Start date
2008-09-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The transversus abdominis plane (TAP) block is a local anaesthetic technique that has been developed in recent years for pain relief after abdominal surgey. It has been shown to work after caesarean delivery when performed by skilled operators. We aim to test an ultrasound guided approach to this block for pain relief after caesarean section. Women having elective caesarean sections will be randomly allocated to receive an ultrasound guided TAP block with local anaesthetic or placebo in addition to standard pain relief including morphine. We hope to find women who receive the local anaesthetic have better pain relief, need less morphine and have fewer side effects from morphine after caesarean section.

Interventions

Ultrasound guided transversus abdominis plane (TAP) block with local anaesthetic. At the end of the caesarean section, a TAP block will be performed with either local anaesthetic or placebo. TAP block technique Equipment Ultrasound – 38mm linear array probe 13-6MHz 22G 150mm Stimuplex needle Study drug – 40ml of 0.5% ropivacaine / saline Betadine antiseptic preparation for skin preparation Pulse oximetry to measure heart rate Availability of full monitoring and resuscitation equipment I

Ultrasound guided transversus abdominis plane (TAP) block with local anaesthetic. At the end of the caesarean section, a TAP block will be performed with either local anaesthetic or placebo. TAP block technique Equipment Ultrasound – 38mm linear array probe 13-6MHz 22G 150mm Stimuplex needle Study drug – 40ml of 0.5% ropivacaine / saline Betadine antiseptic preparation for skin preparation Pulse oximetry to measure heart rate Availability of full monitoring and resuscitation equipment Identification of landmarks Ultrasound positioned in the mid axillary line in the axial plane half way between the iliac crest and the costal margin. Structures to be identified: subcutaneous fat, external oblique muscle, internal oblique muscle, transversus abdominis muscle, peritoneum and intraperitoneal structures. As a means of confirmation, the transversus abdominis tends to be darker and less echogenic. If these are not readily identified, the probe may be moved posteriorly to identify the latissimus dorsi muscle which is external to the fascial extension of these muscles. The probe may also be moved anteriorly to the rectus sheath and the fascial planes followed back out laterally. The final position of the probe is to be no further anterior than the anterior axillary line. Oblique angulation may assist with identifying the planes. Landmarks are to be classified as 'unsatisfactory' if any of 1. external oblique, 2. internal oblique, 3. transversus abdominis, or 4. intraperitoneal structures cannot be identified posterior to the anterior axillary line. The block may still be performed if the investigator is satisfied that the transversus abdominis muscle can be differentiated. Views will be considered ‘excellent’ if quadratus lumborum can be seen in addition to the above four structures. If landmark identification is impossible, the block will not be performed. Needle technique The needle is inserted 'in plane' and directed to lie between the internal oblique and transversus abdominis under real time ultrasound guidance. To confirm location, 2ml of local anaesthetic can be injected. Once position is satisfactory, local anaesthetic is then injected in 5ml aliquots with aspiration between injection to a total of 20ml each side. Appropriate placement will be judged as production of an echolucent plane between the two muscles. Visible separation of muscle bundles of the internal oblique considered superficial placement. Separation of muscle bundles of the transversus abdominis indicates deep placement. Superficial or deep placement requires the needle to be repositioned. Intervention drug The active treatment arm will receive 20ml of 0.5% ropivacaine on each side (total 200mg ropivacaine). The placebo arm will receive 20ml saline on each side. The local anaesthetic duration of action is expected to be between 12 and 24 hours.

Sponsors

Mater Misericordiae Health Services Brisbane Ltd
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients having elective caesarean sections under spinal or combined spinal epidural anaesthesia.

Exclusion criteria

Conditions associated with opioid tolerance: regular opioid analgesia use in the last three months, previous intravenous (IV) drug use Transversus abdominis plane block technically difficult to perform: obesity (body mass index (BMI) > 35) Contraindication to TAPB: local sepsis, local anaesthetic allergy, abnormal anatomy preventing spread of local anaesthetic (for example nephrectomy scars) Contraindications to non-steroidal anti-inflammatory drugs: renal dysfunction, peptic ulcer disease, aspirin sensitive asthma, pregnancy induced hypertension/pre-eclampsia Contraindications to neuraxial anaesthesia Planned general anaesthesia Risk of local anaesthetic toxicity: booking-in weight less than 50kg. Other local anaesthetic administration.

Outcome results

None listed

Source: ANZCTR · Data processed: Apr 2, 2026