None listed
Conditions
Brief summary
A 14 week study investigating whether whole grain rich diets have beneficial effects on the markers of metabolic syndrome compared to diets rich in refined grains. There will be 2 different diets of 6 weeks each duration. Participants will be required to follow one diet for 6 weeks, then a 2 week "Wash out" (normal eating pattern) before following the second diet for 6 weeks. The study will compare the effect of a diet rich in whole grain foods versus a diet rich in refined grain foods on glucose levels and clot breakdown.
Interventions
Participants will be randomised to 1 of 2 treatments of 6 weeks duration each and crossed over at the end of each 6 weeks to the alternative. The treatments are either test foods (rice, cereal, bread) consumed daily containing either wholegrain or refined flour. Rice (white/brown) is 60gram raw weight per day, cereal is(weeties/cornflakes) 70gram per day, bread (white/wholemeal multigrain) is 6 slices per day. The wholegrain and refined foods will provide 55% of the total energy of the participa
Participants will be randomised to 1 of 2 treatments of 6 weeks duration each and crossed over at the end of each 6 weeks to the alternative. The treatments are either test foods (rice, cereal, bread) consumed daily containing either wholegrain or refined flour. Rice (white/brown) is 60gram raw weight per day, cereal is(weeties/cornflakes) 70gram per day, bread (white/wholemeal multigrain) is 6 slices per day. The wholegrain and refined foods will provide 55% of the total energy of the participants diet (based on 8000 kilojoules). Participants will be required to incorporate the test foods into their existing diet by replacing like foods. In this way efforts will be made to keep the diet kilojoule stable and hence participant weight stable. There is a 2 week washout period between each treatment phase and participants will consume their usual diet for this time.
Sponsors
Commonwealth Scientific and Industrial Research Organisation (CSIRO) Human Nutrition
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Weight not greater than 150kg. Metabolic syndrome (International Diabetes Federation (IDF) 2006 definition: waist circumference >94cm for men and 80cm for women plus 2 of the following: fasting Triglycerides>1.7 mmol/l, High Density Lipoprotein (HDL) cholesterol< 1.03 (male) or 1.29 (female) , blood pressure> 130/85 or on antihypertensive medication, fasting glucose >5.6mmol/L). Participants must understand the procedures involved and agree to participate in the study by giving full informed, written consent. No abnormality of clinical significance on medical history. If female, not pregnant or breast feeding.
Exclusion criteria
Coeliac disease or gluten intolerance. Have Type 1 or 2 Diabetes. Have proteinuria, a malignancy, or a history of metabolic disease such as liver, kidney, unstable cardiovascular, clinically significant respiratory or gastrointestinal disease that impairs normal functioning, or are pregnant or lactating. Have high uncontrolled hypertension (resting recumbent blood pressure (BP) >160/100 mmHg). History of heavy alcohol consumption (> 5 Standard drinks/day). Currently on a weight reducing diet. Unable to comprehend or cope with study requirements.
Outcome results
None listed