Prophylactic Antibiotics for spontaneous prelabor rupture of membranes at term

Prophylactic antibiotics for spontaneous prelabor rupture of membranes at term to reduce early neonatal sepsis

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000501347

Acronym

PAST PROM

Enrollment

1640

Registered

2008-09-30

Start date

2009-06-01

Completion date

2011-01-15

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study will investigate the value of prescribing antibiotics for women who have a rupture of fetal membranes before labor at term. There is still a gap in our knowledge regarding the best practice for women with prelabor rupture of membranes at term

Interventions

prophylactic antibiotics ampicillin/flucloxacillin 500 mg intravenously every 6 hours started on admission till delivery

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

spontaneous rupture of fetal membranes at 36 weeks gestation or beyond

Exclusion criteria

chorioamnionitis prolonged rupture of membranes >24

Outcome results