None listed
Conditions
Brief summary
The present study aims to compare a brief structured psychological intervention (IPC) with the use of antidepressants (SSRI) for the treatment of major depression in primary care. The research will evaluate the efficacy of the IPC and antidepressant and it will also evaluate the efficacy of a combined therapy for non responder patients. Finally it will be tested the hypothesis that this psychological approach can reduce relapses in one year compared with those related to the use of andepressants.
Interventions
Interpersonal counseling (IPC) .IPC is a short-term highly-structured psychological intervention, derived from Interpersonal Psychotherapy (IPT) and suitable for different medical contexts.IPC is a treatment of six thirty-minute sessions, with the initial session being longer (1 hour). IPC is self-dosing: the patient determines the length of treatment, many patients feel satisfied with fewer than six sessions.In our study IPC have been adapted to accommodate needs of patients with Major Depression. In the trial the recommended number of counseling sessions is six-eight thirty-minute sessions weekly. Therapist determines if there is need of one or two additional session (6+1 or 6 + 2).IPC is delivered by residents in psychiatry, or in clinical psychology .They attended a 3-days seminar on interpersonal theory’s foundations and IPC structure and techniques; clinical examples were also discussed. Subsequently, monthly supervisions were scheduled with an IPT supervisor in order to discuss cases and to warrant the intervention’s consistency. IPC sessions were videotaped, after a signed consent was obtained from the patient, and discussed during supervisions. Patients with a HDRS score > or =13 at 2-months follow-up will receive a combined treatment including IPC and SSRI. In particular those in IPC arm begin the antidepressant therapy and will continue IPC for further 4-6 sessions.
Sponsors
Study design
Eligibility
Inclusion criteria
Adult patients (> or =18 years old)suffering from a Major Depression episode according to the DSM-IV criteria and having a score on Hamilton Depression Rating Scale (HDRS) > or =13 are eligible for the study.
Exclusion criteria
Exclusion criteria are: more than one clinically significant depressive episode in personal history, moderate to high current suicide risk, current or past episodes of mania or hypomania, psychotic disorders, cognitive impairment (Mini Mental State Examination score =27), borderline or anti-social personality disorders, current substance abuse or dependence. Furthermore, patients with poor knowledge of Italian language were excluded because they could not complete the scheduled assessments. Finally, pregnant or breastfeeding women and patients taking antidepressant drugs, mood stabilizers, antipsychotic agents or receving any kind of psychotherapy were excluded