The Protein StudyThe effect of protein intake on circulating inflammatory markers in women with obesity

The effect of protein intake on circulating inflammatory markers in women with obesity

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000450314

Enrollment

Registered

2008-09-15

Start date

2008-07-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Pro-inflammatory cytokines concentrations are elevated in the fasting and postprandial state and are thought to contribute to the high risk of insulin resistance and type 2 diabetes in obesity. Ingestion of protein and especially dairy protein, increases the secretion of insulin that has anti-inflammatory activity. The study aims to determine whether ingestion of dairy protein with or without carbohydrate decreases postprandial levels of pro-inflammatory cytokines in obese women. The findings will be highly relevant to the use of high -protein diets in the management of obesity and type 2 diabetes.

Interventions

All participants consume 2 protein meals consisting of 19.5gms of dairy protein per meal. The meals are consumed on 2 different occasions with an interval of at least 1 week between the meals.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Healthy volunteers

Inclusion criteria

25 abdominally obese women Body Mass Index (BMI) > 30 and waist circumference > 88cm)

Exclusion criteria

Cigarette smoking, cardiovascular disease, infections or other serious medical problems and use of some medications

Outcome results