None listed
Conditions
Brief summary
The aim of the project is to investigate the usefulness of novel markers (‘biomarkers’) in predicting the risk of experiencing a CVE (defined as a composite of STEMI or NSTEMI, stroke, or death) during or after vascular surgery in patients with severe peripheral vascular disease (PVD) who require surgical correction or bypass. The risk of a CVE in this group of patients is typically about 20-25%. The prevalence of coronary artery disease in this select group of participants approaches 50% and increases with age. Current risk assessment methods, although useful, may not necessarily detect all at-risk patients, especially those without pre-existing symptoms of ischaemic heart disease such as angina or previous myocardial infarcts. This study will assess if newer methods can help detect at-risk patients who may not have symptoms of heart disease but who are still at risk of developing a CVE peri-operatively. Examples of novel biomarkers measured preoperatively include endothelial function testing by fingertip arterial tonometry, iron studies, myeloperoxidase, matrix metalloproteinase, and lipidomic profiling.
Interventions
Obervational study. The study aims to observe whether a certain risk markers in blood correlate with the occurrence of cardiovascular events (CVE) following major vascular surgery. The intended duration of observation is at least 30 days following vascular surgery and up to 1 year per patient.
Sponsors
The Alfred Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients >18 years of age. Vascular surgery either urgent, elective or semi-elective including: open repair of abdominal aortic aneurysm (AAA); supra-inguinal or infra-inguinal bypass or reconstructive surgery (e.g. aorto-bifemoral grafting).
Exclusion criteria
Unwilling to consent. Myocardial infarction <6weeks. Percutaneous coronary intervention with bare stent <6weeks; or drug-eluting stent <12 months.
Outcome results
None listed