Effect of statin ingestion on muscle function at rest and following acute exercise in humans

Effect of simvastatin ingestion on muscle function at rest and following acute exercise in healthy humans

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000423314

Enrollment

Registered

2008-08-25

Start date

2008-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Th eprimary purpose of this study is the examine the effect of statin medication on skeletal muscle metabolism at rest and during and after acute exercise. We hypothesise that high dose statin ingestion will lead to reductions in mitochondrial function and/or number and thus altering muscle metabolism.

Interventions

Healthy males (18-35yrs) will ingest 80 mg/day of simvastatin for 28 days and then perform a single bout (1hr) of prolonger moderate intensiity exercise.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Diagnosis

Masking

Blinded (masking used)

Eligibility

Sex/Gender

Male

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy males, (18-35yrs) normal renal, liver and thyroid function. no other mediciations for histories of diease.

Exclusion criteria

abnormal renal, thyroid and liver function

Outcome results