Mechanical Ventilator as a physical therapy device to improve airway clearance in critical care patients.

Mechanical ventilator hyperinflation improves sputum production and respiratory mechanics in hypersecretive critical care patients.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000420347

Enrollment

Registered

2008-08-25

Start date

2006-06-25

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of this study was to investigate the effects of a hyperinflation protocol using pressure support ventilation in removing secretions and improving ventilation of hypersecretive critical care patients. We hypothesized that this protocol would improve sputum production and respiratory mechanics, without clinically relevant adverse hemodinamic effects.

Interventions

Ventilator hyperinflation treatment (VHT). Patients were in side-lying position, so that the more affected lung was upper-most. The ventilatory mode was changed to pressure support ventilation. The pressure support was adjusted above the positive end expiratory pressure to reach 40 cmH2O of peak pressure. The treatment lasted 30 minutes (1 session). All participants received both treatments (intervention and comparator/control) in one day, with a washout period of five hours between them.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Mechanical ventilation, pulmonary infection and hypersecretion.

Exclusion criteria

Hemodinamic instability, absence of respiratory drive, acute bronchospasm, acute respiratory distress syndrome, atelectasis, immediate postoperative neuro-surgery, untreated pneumothorax, lung hemorrhage, impossibility to keep on lateral decubitus position.

Outcome results