Effects of dietary administration of n-3 polyunsaturated fatty acids on cardiac electrophysiology in humans

Effects of dietary administration of n-3 polyunsaturated fatty acids on cardiac electrophysiology in humans undergoing cardiac electrophysiology testing and/or ablation for supraventricular tachycardia

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000341325

Enrollment

Registered

2008-07-18

Start date

2008-07-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In this study, we will examine the effects of n-3 fatty acids on the electrophysiology of the heart in a bid to determine possible mechanisms for anti-arrhythmic effects of n-3 fatty acids

Interventions

liquid fish oil containing 18% eicosapentaenoic acid (EPA) + 12% docosahexaenoic acid (DHA). 15 ml/day for 21 days days prior to electrophysiology study/ablation

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

undergoing an elective cardiac electrophysiology procedure (electrophysiology study +/- ablation for supraventricular tachycardia

Exclusion criteria

a) Cardiac rhythm other than sinus rhythm at the time of the procedure b) Current use of fish oil supplements c) Known impaired lipid metabolism d) Uncontrolled diabetes mellitus e) Known allergy to fish f) Current use of anti-arrhythmics other than ß-blockers, or use of amiodarone within the past 3 months g) New York Heart Association Grade II-IV heart failure h) Known bleeding disorder

Outcome results