None listed
Conditions
Brief summary
Sports anti doping study. The aim of the study is to obtain specimens of urine and blood from voluneers who have been given an injection of insulin. These samples will then be used to develop tests which will help detect the presence of insulin in the blood and urine of elite athletes who have used insulin illicitly to enhance their performance.
Interventions
Type I diabetic participants take their usual insulin dose and provide blood and urine samples at baseline and for up to 24 hours.
Non diabetic participants are administered intravenous (IV) Actrapid insulin 0.05iu/kg at visit 1, 70g oral glucose at visit 2 and placebo at visit 3. Blood and urine samples are collected at each visit at baseline then for up to 24 hours. There is a 5 day washout period between visit 1 (insulin administration) and visit 2 (glucose administration). There is no spec
Type I diabetic participants take their usual insulin dose and provide blood and urine samples at baseline and for up to 24 hours. Non diabetic participants are administered intravenous (IV) Actrapid insulin 0.05iu/kg at visit 1, 70g oral glucose at visit 2 and placebo at visit 3. Blood and urine samples are collected at each visit at baseline then for up to 24 hours. There is a 5 day washout period between visit 1 (insulin administration) and visit 2 (glucose administration). There is no specified washout period between visit 2 and visit 3 (placebo administration).
Sponsors
Concord Repatriation General Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
Type I diabetics: on insulin therapy Male or female Aged 18 to 45. Non diabetics: Healthy Male or female Aged 18 to 45
Exclusion criteria
In non diabetic group: Coronary artery disease epilepsy diabetes elite athletes pregnancy
Outcome results
None listed