None listed
Conditions
Brief summary
We already know that blood glucose levels relate to the long term vascular complications in type I diabetes. There have been other studies that suggest that blood glucose variability (i.e. how much the blood glucose levels vary through the day) may also be an important factor. The purpose of this study is to look at blood vessel function and glucose variability in children whilst they are on insulin injections compared with shortly after starting an insulin pump. The hypotheses to be tested are: •Commencing children with type I diabetes on a insulin pump improves how blood vessels work •Commencing children with type I diabetes on a insulin pump reduces glucose variability •The improvement in how the blood vessels is due to reduced glucose variability independent of other changes in vascular risk factors.
Interventions
continuous subcutaneous insulin infusion (insulin pump), dose at calculated based on normal insulin requirements, study to continue for 3 weeks but patients to continue on insulin pump after study is complete
Sponsors
Adelaide Children, Youth abd Women's Health Service
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
8 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
Children with type I diabetes from the diabetes clinic at the Adelaide Chidren, Youth and Women's Health Service on the waiting list to commence an insulin pump
Exclusion criteria
smoking, history of allergic reaction to nitrates or nitrites, pregnancy
Outcome results
None listed