A study to investigate the effects of nebulised magnesium in severe exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

A randomised, double-blind, parallel group, placebo-controlled study investigating the efficacy and tolerability of adjuvant nebulised magnesium therapy in conjunction with standard emergency department treatment of acute severe exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000167369

Enrollment

200

Registered

2008-04-04

Start date

2008-05-22

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The treatment intervention is 2.5ml of 0.25mmol/mL magnesium sulphate solution given as a nebulised inhalation on 3 occasions (total dose 0.625mmol). The 3 doses are administered at time (T) = 0min, T= 30min and T = 60min. Subjects will also receive standard therapy for a severe COPD exacerbation in accordance with emergency department protocols and their clinical presentation.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

36 Years to No maximum

Healthy volunteers

Inclusion criteria

Aged greater than 35 years old; Doctor diagnosis of COPD, emphysema or chronic bronchitis; Presentation to the Emergency Department (ED) with a severe exacerbation of COPD (initial FEV1 < or = 50% predicted)

Exclusion criteria

Patients requiring intubation or non-invasive ventilation on arrival, or too unwell to perform spirometry at presentation; Another serious medical condition that would prevent their participation in the trial; Pregnant women; Pneumothorax

Outcome results