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Detecting injury to the heart after emergency orthopaedic surgery by means of a blood test (called Troponin I) and determining if care by the cardiology unit can improve mortality at one year compared to usual care

Troponin rise after emergency orthopaedic-geriatric surgery randomised to standard care versus cardiology care and its associaton with one year mortality

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12608000165381
Enrollment
154
Registered
2008-04-04
Start date
2008-04-07
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project will determine whether standard care or cardiology care improves survival for patients undergoing emergency orthopaedic-geriatric surgery with a troponin rise. A pilot study conducted at The Northern Hospital in 2006 revealed that at one year mortality rate was 21% in this population and those with a troponin rise were more at risk of dying. Therefore, this RCT is proposed to see if cardiology care is any better than standard care to improve survival.

Interventions

All recruited patients will have troponin blood tests and electrocardiographs (ECGs) done on post-operative days 1,2 and 3. Patients with a post-operative troponin rise will then be randomised to either standard care or cardiology care (the intervention). The cardiology care protocol involves a "total package" of care. This involves transfer to the coronary care unit for 24hours, review by a cardiologist and consideration for catheterisation if symptomatic. If not for catheterisation or if

All recruited patients will have troponin blood tests and electrocardiographs (ECGs) done on post-operative days 1,2 and 3. Patients with a post-operative troponin rise will then be randomised to either standard care or cardiology care (the intervention). The cardiology care protocol involves a "total package" of care. This involves transfer to the coronary care unit for 24hours, review by a cardiologist and consideration for catheterisation if symptomatic. If not for catheterisation or if asymptomatic cardiology treatment will involve medical management with aspirin, beta blocker, statin +/- Angiotensin Converting Enzyme (ACE) inhibitor. All medications will be given orally with the dose and frequency at the discretion of the cardiologist. Duration of medication treatment will be for at least the duration of hospitalization with ongoing medication treatment at the discretion of the cardiologist. Patients randomised to coronary care will also have cardiac investigations including serial ECGs, chest x-ray, lipid profile, echocardiogram. All patients randomised to coronary care will also receive outpatient follow up by a cardiologist and a functional cardiac study (either dobutamine stress echocardiography or thallium stress test, only if they are a candidate for catheterisation in the future).

Sponsors

Dr Carol Chong
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients over 60 admited under the orthopaedic unit who undergo emergency surgery

Exclusion criteria

Elective surgery, die before surgery, admitted under a different unit, patients with an estimated mortality of less than 1 year (eg. terminal cancer), nursing home patients.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026