Screening for Colorectal Cancer in Recipients of Kidney Transplants

Conditions

None listed

Brief summary

The risk of cancer, including colorectal cancer is increased in recipients of kidney transplants. This study is designed to evaluate the standard population screening tools for colorectal cancer, ie faecal occult blood testing and colonoscopy, in this high risk population. All recruited patients will undergo both of these screening tests, and from this we will investigate the rates of colorectal cancer and pre-cancerous growths in this population, and the usefulness of the two screening tests for this group of patients.

Collins MG, Teo E, Cole SR, Chan CY, McDonald SP, Russ GR, Young GP, Bampton PA, Coates PT.

2012-07-2534 citations

10.1136/bmj.e4657

Interventions

1. Faecal occult blood testing (FOBT). Participants will perform FOBT following enrolment. This involves using a patient kit to sample their own stools for the presence of blood, mailing their testing kit in to a central lab once it is completed. Testing will be conducted once but may involve sampling several stools. 2. Colonoscopy. All participants will also undergo colonoscopy following the completion of FOBT, regardless of the result. This will be performed within a target of 3 months post en

1. Faecal occult blood testing (FOBT). Participants will perform FOBT following enrolment. This involves using a patient kit to sample their own stools for the presence of blood, mailing their testing kit in to a central lab once it is completed. Testing will be conducted once but may involve sampling several stools. 2. Colonoscopy. All participants will also undergo colonoscopy following the completion of FOBT, regardless of the result. This will be performed within a target of 3 months post enrolment.

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Healthy volunteers

No

Inclusion criteria

- Kidney transplant recipients in South Australia >=50 years old, more than 6 months post transplant - Willing and able to give informed consent

Exclusion criteria

- Active unstable cardiopulmonary disease - Terminal illness, life threatening malignancy - Bleeding disorders or unable to stop oral anti-coagulants for colonoscopy - Colonoscopy within 12 months prior to enrolment - Failed kidney transplant and return to dialysis prior to enrolment - Symptoms or signs suggestive of colorectal cancer - Previous personal history of colorectal cancer, advanced adenoma or chronic ulcerative colitis - Family history of Familial Adenomatous Polyposis (FAP) or Hereditary non-polyposis colorectal cancer (HNPCC)

Outcome results