None listed
Conditions
Brief summary
Several formulations have been used for IDPN and have ranged from those with minimal provision of nutrients to those that deliver significant amounts of calories and amino acids. Administration of lipid was originally considered to be contraindicated in IDPN but studies suggest otherwise and lipids are now used routinely. Austin Health is the first dialysis centre in the world to use standard lipid only IDPN solution. Since then a 20% lipid 500 ml or 30% lipid 250 ml solutions are routinely used in our haemodialysis patients requiring IDPN support. What effect if any is this practice having? Would the use of a more standardised practice of protein, lipid and dextrose combined solution be more beneficial?
Interventions
Malnourished haemodialysis patients will be randomised to 1000kcal 20% lipid ClinOleic Intra-Dialytic Parenteral Nutrition (IDPN) solution given via the dialysis line during the dialysis session 3 x week for up to 3 months.
Sponsors
Austin Health
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Haemodialysis patients who had been dialyzing at Austin Health for more than 3 months will be asked to participate in the study when they present with at least 2 of the following five criteria of malnutrition 1. Body Mass Index (BMI) <20 2. Weight loss >10% in 6 months 3. Serum albumin < 30 4. Prealbumin <300mg/l 5. normalised protein catabolic rate (nPCR) <1g/kg per day
Exclusion criteria
Malignancy Associated disease compromising 3 month survival
Outcome results
None listed